"In-universe" means that it is something valid or correct from the point of view of fictional story (or a universe of stories, e.g. Harry Potter)
This is opposite of "out of universe", aka "outside the 4th wall" - things which are true in our real world.
A good example of in-universe vs. out-of-universe information is:
Q: Why did this character on fiction TV show die?
A: (in-universe): Because this other character was a son of a person the first character killed, and they wanted revenge.
A: (out-of-universe): Because the character was played by an actor who was demanding a salary too high for the budget.