This question is similar to Should all questions without explicit canon answers be closed?, except that I'm going a step further in asking about topics where the lack of canon makes most questions unanswerable, or open to answers along the lines of "there is no answer".
They might be different questions, but because of the nature of the show and the deliberate lack of canon surrounding it, I could foresee a lot of questions being answered with almost an exact copy-and-paste of the accepted answer to the question above.
For example, I might ask
Why was the Satellite of Love shaped like a bone? Was there a reason for this given in-universe?
Now, I don't know the answer to this question, and it might have a legitimate answer. However, my instincts are telling me that the real answer is going to be some form of
If you're wondering how he eats and breathes
And other science facts (LA LA LA)
Just repeat to yourself it's just a show
I should really just relax
Should tags like this have it noted in their wiki that some forms of questions are not likely to be answerable?
Note that MST3K is just an example, and there could be plenty of others in the same boat.