Ambergris
Jeff VanderMeer's weird saga of the really weird city Ambergris, a city of saints and madmen, as depicted in the novella Dradin, in Love, the novels Shriek: An Afterword and Finch: A Novel, and several short stories.
It's got it all: tyrannical squid, terrifying small people, opera star politicians, warring publishing houses, living saints, mendacious art dealers, people turning into fungus, plus a murder mystery (actually several). It seems like a goldmine for questions.